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Yeast cytosolic RNA can surprisingly be imported into human mitochondria and it has been shown that the imported tRNALysCUU can partly rescue the biochemical defect in cell lines carrying the m.8344A>G MERRF mutation [87].
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Omp85 Ngo is imported into human mitochondria and forms complexes in the OMM, whereas PorB Ngo does not assemble into the OMM upon entering mitochondria [ 15].
Similar to Omp85 Ngo and BamA Eco, only neisserial PorB Ngo but not the homologous E. coli protein OmpC Eco is imported into human mitochondria.
Recently, we could show that only Omp85 Ngo but not BamA Eco is imported into human mitochondria and assembled in the OMM [ 15].
Additionally, although the TFs RelA and STAT3, previously identified as being imported into human mitochondria (reviewed in Szczepanek et al. 2012), were included in the ENCODE data set, we did not identify any relevant significant ChIP-seq peaks in any of the tested cell lines.
Therefore, only one isoform of Par17 (Par17-QR) was used for in vitro import experiments with isolated mitochondria; these experiments clearly showed human Par17 to be imported into the matrix of human, rat and yeast mitochondria.
The move allows fresh and tinned genetically modified sweetcorn to be imported into EU states for human consumption.
Might all these RNAs be imported into mitochondria by the PNPase-dependent import pathway?
Presumably, nutrients can be imported into predators through this junction.
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