Compared with γ-crystallins, β-crystallins generally possess longer N- and C-terminal extensions (Berbers et al., 1983; David et al., 1996), which are believed to be important to regulate the oligomerization and folding of β-crystallins (David et al., 1996; Leng et al., 2014; Dolinska et al., 2009; Sergeev et al., 1998; Kroone et al., 1994).
Based on the results from this study and the functions during the gene expression, we think that differences in methylation levels and patterns may be important to regulate tissue-specific gene expression and cell differentiation, however we need to perform further studies to confirm this.
6, 9, 10 Because TMPRSS2, 5′-fusion partners, are upregulated by androgen, AR has been supposed to be important to regulate the fusion of genes in prostate cancer.
The R-NSC stage-specific inclusion of alternative exon suggests that the exon inclusion may be important to regulate R-NSC-specific functional properties.
Akt and c-Src phosphorylations were persistently elevated in HGF-treated MDA-MB231 cells, suggesting that these cell signalling pathways might be important to regulate changes of invasiveness and CXCR4 expression.
More recently, Eph-Ephrin signaling was shown to be important to regulate the invasiveness of prostate cancer cells towards stromal fibroblast via an inhibition of the CIL response in the malignant cells (Astin et al., 2010).
Still, from a perspective of emotion regulation (Gross 1998), it is important to regulate these negative emotions even if they represent valuable feedback on the progress of problem solving (Hannula 2015).
"It's important to regulate ahead of time," she said.
It's true they've been out of control, so it's important to regulate in some way, but whatever behaviour is curbed will simply emerge in another form".
