Sentence examples for be important to mediate from inspiring English sources

However, immunization with only JOL916-JOL1229 mixture showed enhanced intestinal sIgA immune response, which may be important to mediate antibody-dependent T-cell-mediated cytotoxicity against Salmonella[ 29].

Thus, some activities, although only transiently associated with shelterin, may be important to mediate its role in telomere function.

Instead, one might speculate that dsRNA binding could be important to mediate the rapid export observed in the absence of C33 or of a functional CHCC motif.

Integrity of Scc1 might be important to mediate its stabilising function between Smc1 and Smc3, and after cleavage, its ability to connect the Smc heads might be disrupted (Gruber et al, 2003).

Interestingly, it has been recently shown that deletion of Trf1 induces phosphorylation of both the ATR and ATM downstream kinases CHK1 and CHK2, respectively, suggesting that both checkpoint kinases may be important to mediate telomere dysfunction owing to telomere uncapping (Martinez et al., 2009; Sfeir et al., 2009).

The co-localization of Gremlin and TGF-β1 expression in glomeruli and tubular cells suggests that Gremlin may be important to mediating some of the pathological effects of TGF-β1 [ 14].

Since phosphorylation of p57 by p38 induced a reduction on Cdk2 activity, we analysed whether p57 was important to mediate a cell-cycle delay in G1 upon osmostress.

We have observed that RSC is important to mediate nucleosome reorganization at both promoter and coding region of osmo-responsive genes; however, we detect only the recruitment of RSC at the coding regions of stress genes.

Tipin, together with Tim1 and Claspin, is a member of the replication-pausing complex and is important to mediate the intra-S-phase checkpoint (Ito et al, 2001; Mayer et al, 2004; Noguchi et al, 2004; Nedelcheva et al, 2005; Chou and Elledge, 2006; Krogan et al, 2006; Gotter et al, 2007; Unsal-Kacmaz et al, 2007; Yoshizawa-Sugata and Masai, 2007).

Biosynthesis of ethylene and regulation of its activation pathway are important to mediate plant developmental processes and stress responses in plants [ 57, 58].

As a matter of fact, biochemical signal-mediated mechanisms, such as protein protein interaction and cytoskeletal remodeling under mechanical tension are important to mediate mechanical signals as discussed above.