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This may be important to functionally explore as 5-mC and 5-hmC have different reported roles in the context of gene regulation [ 54].
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These results highlight the fact that it is important to functionally validate ChIP-seq experiments, since the presence of binding is not necessarily functionally relevant.
Because a subset of mutations in cancer are not relevant to cancer progression (so-called 'passenger genes'), it is important to functionally validate candidate genes to identify those that are relevant to cancer progression ('cancer driver genes').
Thus, it is important to functionally characterise miRNAs, such as miR-183 that are dysregulated in breast cancer and establish what effect this dysregulation may have on tumour behaviour.
Overall, a complex set of ligands and cytokines appear to be important to initiate GC structure functionally and define their anatomic site.
Since specific functions of TPS genes cannot be accurately predicted from sequence analysis alone, it was important to clone and functionally characterize VvTPS full length (FL cDNAs.
It is important to understand that both thermostats are functionally identical when working in Heat mode.
It is therefore important to functionally annotate the tens of thousands of genes for which this information is currently lacking.
It is now important to functionally test the mechanisms linking mechanical stimulation with Wnt signalling.
The discovery of aberrant DNA methylation in complex diseases, especially in cancer, has focused investigation on specific genes of interest and on genomic regions assumed to be important functionally, such as promoters and CpG islands [ 38, 39].
HLA-A allelic product encoded by A*3201 is likely to be functionally important to GBM.
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CEO of Professional Science Editing for Scientists @ prosciediting.com