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The results implied that PPARs might be important regulators in mouse embryonic β-cell development.
In addition to survival, IAPs are thought to be important regulators in differentiation, innate immune response and cell motility [ 52].
In the past decade, numerous small and long non-coding RNAs (lncRNA) have been shown to be important regulators in both normal development and disease [ 59, 99].
MiRNAs in particular have been shown to be important regulators in cancer and other diseases and show promise as predictive biomarkers for diagnosis and prognosis.
In addition, Akt1 and Akt2 were shown to be important regulators in the activation of DNA-dependent protein kinase, a key enzyme of nonhomologous end joining of the DNA repair pathway.
The null models based on binding motifs show that there are other TFs not profiled in K562 which may be important regulators in other cells, like HSC and T-cells.
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Human aurora kinase-A (AURKA) and -B (AURKB) are important regulators in mitosis during the cell cycle.
MiRNAs are important regulators in animal development.
Indeed, both Zfp36 and Zc3h12a are important regulators in macrophage inflammation [4], [5].
Both Grb2-family adapters found to bind to HD-PTP are important regulators in lymphocytes signaling and development [24] [29].
VEGF isoforms have different affinities for heparan sulphate proteoglycan (HSPG) as well as for VEGF receptors; HSPGs are important regulators in vascular development.
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