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Importantly, the results from previous clinical studies suggest that CI of beta-lactam antibiotics is unlikely to be advantageous for all hospitalized patients but may be important in specific patient cohorts.
Some of the listed miRNAs were previously reported to be important in specific brain regions.
Additional or alternative criteria, for example criteria capturing other aspects of QI interventions 3 building on the QI-MQCS may be important in specific research contexts.
Thus, while no-cost mutations may not be a general explanation for why antibiotic resistance persists in the absence of drug, it may be important in specific cases.
In addition to observational cohort studies and RCTs focusing on specific patient groups, mechanistic studies are necessary to further elucidate the molecular and physiologic rationale for the beneficial effects of albumin and explore how albumin's pleiotropic actions may be important in specific groups of critically ill patients.
This subdivision might be important in specific clinical contexts (e.g. assessment of Vitamin D levels in elderly); in the context of our study the distinction between health categories A1 and A2 is less relevant and therefore these participants will be considered together in all statistical analysis.
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This algorithm is important in specific issues with speed and precision of convergence to optimality.
According to the best of our knowledge, there is no previous report on morphology optimization of number of beads per unit area in nanofibrous active dressings by RSM which is important in specific applications.
Further work in vitro and in vivo will be necessary to determine the extent to which these effects are important in specific biological processes.
Mutational studies have been implemented to discover sites that are important in specific interactions between these Rieske centers and their redox partners.
The trafficking of cargoes is also required for maintaining the polarity of cells, which is important in specific tissues 4, 5. Whereas the secretory pathway functions in the forward trafficking of proteins, endocytosis pathways also exist that contribute to the internalization of plasma membrane and plasma membrane proteins, and in the uptake of nutrients 6, 7 (Fig. 1).
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