Sentence examples for be important in progression from inspiring English sources

Although loss of LKB1 by itself may not be sufficient for RCC initiation, it may be important in progression because of its effects on angiogenesis and invasion as demonstrated here.

Because of their degradative effects on the extracellular matrix, the family of gelatinases has been believed to be important in progression and cartilage degradation in this disease, although their precise roles still are to be defined.

The balance of ETA and ETB activation in tumour cells appears to be important in progression of most cancers (Nelson et al, 2003), especially prostate cancer (Kopetz et al, 2002).

However, disruption of the regions of E2 analysed was significantly more frequent in high-grade lesions, and there was a significant association between the 3684C-A varinnthen thE2E2 DNA binding domain and high-grade histology suggesting that this variant may be important in progression to high-grade intraepithelial disease.

Here we report aberrant methylation levels of ABCB1, FOXC1, GSTP1, PPP2R2B and RASSF1A in DCIS and stage I-IV providing evidence that suggests that changes in methylation level is an early event and may also be important in progression to later stages of breast cancer.

Among several pathogenic organisms that accumulate and colonize in the form of plaque, lactobacilli do not play a major part in initiation but are important in progression of the lesion.

EMT plays a prominent role during gastrulation and many of the key molecular players during these processes have been noted to be important in disease progression during adulthood.

These studies suggest that the intraneuronal accumulation of Aβ may be important in disease progression and symptom onset.

MMP14 reveals to be a very intriguing molecule that seems to be important in tumour progression by promoting cell invasion and matrix degradation.

Many of these proteins have been shown to be important in cancer progression, angiogenesis, autophagy and anti-apoptotic mechanisms [3], [18], [19], [20].

The fact that only about half of the mice (9/22) develop tumors suggests that modifier genes may be important in tumor progression.