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Two pathways known to be important in developmental myelination are the Notch-1 and Wnt pathways.
It may be important in developmental processes, since homozygous α2B-KO mice do not breed well [ 2].
This type of transmission, which gives rise to genotype-environment covariance, is considered to be important in developmental psychology.
Its product probably functions as an adhesion molecule and/or signaling receptor and is likely to be important in developmental processes and cell communication.
For the identified family members, we observed a conserved expression signature: All mir-34 family miRNAs are upregulated in dauer and iL3, suggesting that they may be important in developmental arrest in free-living and parasitic nematodes.
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TGF β signaling is regulated by cytoplasmic kinases (Bone Morphogenic Proteins – not discussed herein), Retinoic Acid-Retinoic Acid Receptor (RAR) and is important in developmental programs and maintaining an epithelial state.
Canonical WNT signaling, named after the homology of WNT-genes with int-1 and wingless in Drosophila, is important in developmental signaling [15], [16].
Interestingly, Wnt signaling is important in developmental processes and might therefore also play a role in LC differentiation.
The poised promoter set of embryonic stem cells is important in developmental processes and found to be methylated in various cancer types [ 31, 32].
The majority of known genes regulated through the Wnt and TCF/β-catenin pathways are important in developmental and differentiation mechanisms in complex organisms.
Further, they identified a set of 353 genes (Table S1; see Supplementary Material available online at http://dx.doi.org/10.1155/2014/725780) that are cobound by all the three TFs in human ES cells and found that this set includes a substantial number of genes that encode homeodomain TFs, which are important in developmental regulation of ES cells.
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