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Notably, the vast majority of tumours with the 11q13 amplification had large deletions in the telomeric region of 11q22, including other genes known to be important in cell death in cancer such as ATM and CASP1, 4, 5 and 12. Amplification of 11q13 was anti-correlated with CASP8 mutations, suggesting an alternative function of CASP8 and FADD in cell death/NF-κB activation35.
Endogenous electric signals, such as spatial gradients of resting potential among non-excitable cells in vivo, have also been shown to be important in cell proliferation, differentiation, migration, and tissue regeneration, and may therefore have as-yet unexplored therapeutic potential for regulating wound healing in bone tissue.
Rho kinases (ROCKs) mediate cell contraction, local adhesion, and cell motility, which are considered to be important in cell differentiation.
Membrane blebbing has also been suggested to be important in cell migration and cancer cell invasion (See a review by Fackler and Grosse, 2008) [46].
The PI3K/Akt pathway is known to be important in cell survival, growth, migration, and invasion.
Besides caspase-mediated apoptosis, autophagy is recently implicated to be important in cell survival and death.
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In this way, one of the main TCA cycle functions comes to the forefront by providing metabolic intermediates for anabolic biosynthesis, a feature likely to be important in cells coping with mild stress20.
The identification of mutations in CXCR4 in individuals with WHIM syndrome represents the first example of aberrant chemokine receptor function causing human disease and suggests that the receptor may be important in cell-mediated immunity to HPV infection.
Quantitative analysis of cell mitosis, the process by which cells regenerate, is important in cell biology.
Background: Glycine betaine is important in cell volume regulation and in remethylating homocysteine, a vascular risk factor.
Lecithin, also called Phosphatidyl Choline, any of a group of phospholipids (phosphoglycerides) that are important in cell structure and metabolism.
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