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Synchronization of neuronal firing is widely thought to be important in brain function.
There is also growing evidence that the brain has lymphatic vessels within the dura mater and these may be important in brain fluid drainage [ 16].
Although this conclusion is speculative at this time, our analysis suggests that divergence in cis-regulatory elements near genes associated with neural plasticity and synaptogenesis might be important in brain evolution.
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Omega fatty acids are important in brain function, growth, and development.
Central thyroid hormone signaling is important in brain function/dysfunction, including affective disorders and depression.
The results presented here demonstrate that the lipid signals are important in brain metastases characterization.
The opposite expression pattern between miR-199a/199b/214 and their 168 refined predicted targets in fetal/adult brain and non-brain tissues strongly suggested that repressed expression of these three miRNAs is important in brain development.
FAK is important in brain development [ 22, 23] and appears to play a critical role in the formation of tumors and in malignancy of cancer cells, controlling their invasive and metastatic capacities (see [ 24]).
Concurrent with a role as a monoaminergic modulator, knock-out mice show changes in their dopaminergic system compared to wild types including increased high-affinity dopamine receptor D2[ 22] and higher neuronal firing rates in the ventral tegmental area [ 9, 22], which is important in brain reward circuitry [ 9].
The researchers then looked at whether those nine metabolites might be important in human brain evolution.
Some of the listed miRNAs were previously reported to be important in specific brain regions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com