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Although FCA has not been previously implicated in local adaptation, it plays an important role in the flowering time pathway in A. thaliana [71], [72], and is thought to be important in adaptation to new flowering regimes [73].
This result supports the hypothesis that lineage-specific genes may be important in adaptation [ 4].
Recently we found evidence that polymorphism in the promoter for Ptx (ptxP) may also be important in adaptation [ 23].
Lineage-specific genes, the genes that are restricted to a limited subset of related organisms, may be important in adaptation.
In bacteria, iron metabolism has been shown to be important in adaptation to the environment especially within the host and as a result related to virulence.
Pericyte/EC crosstalk is also integral to physiological angiogenesis [ 59], and is likely to be important in adaptation to hypoxic injury and focal capillary contractility.
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Cyanobacteria are photoautotrophic prokaryotes able to grow in a wide range of ecological environments, and their signal transduction systems are important in adaptation to the environment.
Much research on "Evolution Canyon" has proved that the interslope divergent selection is due to microclimate [ 46, 47] (see the publication list: http://evolution.haifa.ac.il/index.php/component/content/article/29).Different selection pressures in different regions are important in adaptation to local habitats [ 48, 49].
Evidence suggests horizontal gene transfer from other bacterial species, particularly lactobacilli, has been important in adaptation of L. casei to new habitats and lifestyles, but evolution of dairy niche specialists also appears to involve gene decay.
Metabolic inflexibility may also be important in cardiac adaptation to stress [23], [24].
Although, the ontogenic control of postnatal tolerance is incompletely understood, the developmental changes reported in this study that coordinates the downregulation of cell surface expression of TLRs and their signaling molecules and upregulation of negative regulators is likely to be important in postnatal adaptation to initial intestinal colonization.
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