Sentence examples for be important for substrate from inspiring English sources
Medium-chain acyl CoAs are also required and may be important for substrate routing to this pathway.
This review will highlight these recent structures, particularly the non-catalytic ancillary domains, which might be important for substrate recognition.
Substitution of residues predicted to be important for substrate binding (L69, H134, F222, and C284), calcium ion coordination (D54, N168, N224, and D269), and catalytic mechanism of HuPON1 (H285) led to enzyme inactivation.
Val-168 and Leu-169 were found to be important for substrate recognition, and Glu-171 was also found to be important, consistent with its hypothesized role as a Ca(2+ -binding residue.
This model did not include pocket 11 indicating that this sub-pocket might be important for substrate recognition (Figure 1).
Notably, the residue corresponding to E4288.66 in various transporters has been shown to be important for substrate transport [44], [45] and shown to become solvent exposed in the inward-facing conformation of GAT-1 [45].
The aa-sequences of fungal LysM domains are highly variable, and they could therefore be important for substrate-binding specificity and, thus, targeting of the chitinase to its correct place for hydrolysis.
The substrate-binding pocket of the DK17 o-xylene dioxygenase is large enough to accommodate bicyclics and can be divided into three regions (distal, central, and proximal), and hydrophobic interactions in the distal position are important for substrate binding.
Further mutational studies also demonstrated that the hydroxyl groups of Tyr99 in the substrate recognition peptide and Tyr126 in Loop 1 were important for substrate specificity.
The occurrence of multiple amino acid substitutions appears to be common in CYP102A1 natural variants, although it is unclear as yet whether all identified mutations are important for substrate affinity, thermal stability, catalytic activities, and their promiscuity to non-natural substrates.
Here, we demonstrate that Usa1 is important for substrate ubiquitylation.
