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Among the hub transcription factors, HAND1, HMGA1, MYCN and OCT4 are known to be important for stem cell development [27], [52] [54].
These enzymes are shown to be important for stem cell activities.
Some of the signaling pathways such as Notch and NFκB have been shown to be important for stem cell generation.
Analysis of genes previously reported to be important for stem cell maintenance show higher expression in CD44+CD24− cells relative to the other cell populations.
Furthermore, histone mobility in root stem cells appears to be lower than in the surrounding cells, suggesting that flexible chromatin organization might be important for stem cell fate (Rosa et al., 2014).
However, we find factors that are likely to be important for stem cell to niche communication which are also upregulated in cancers that are likely to have derived from deregulated stem cells.
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Lapatinib, it turns out, also inhibits the activity of a protein called the epidermal growth factor receptor, which has been found to be important for stem-cell proliferation.
Development of biomaterials to control the fate of stem cells is important for stem cell based regeneration of bone tissue.
Stem strength i.e., the bending or breaking strength of the culm, is important for stem lodging resistance, particularly for the basal internodes of crops (Zuber et al., 1999).
Identification of novel CM genes and domains in humans will aid our understanding of fundamental epigenetic processes that are important for stem cell differentiation and cancer biology.
These results also indicated that cell-to-cell relationships, probably including paracrine factors, and cellular milieu are important for stem cell differentiation and development.
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