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An additional endo/lysosomal processing enzyme, though not a protease, has been shown to be important for presentation of some, though not all, T cell epitopes in antigens with internal disulphide bonds.
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As poly-LacNAcs are the usual core units for the presentation of some functional glycan epitopes, GlcNAc transferases found to correlate could also be important for the epitope presentation suitable for lectin-based recognition.
In addition, phagosome escape and bacterial persistence in the cytosol is likely to be important for MHC Class I presentation of important antigens [24].
A better understanding of endogenous antigen processing for HLA class II-restricted presentation in HLA class II+ tumor cells could be important for developing approaches to optimize presentation of, yet unidentified, tumor-associated antigens (TAAs), thereby circumventing tumor immune escape.
SPI-2 encoded proteins like SifA, SspH2, SlrP, PipB2, and SopD2 were found to be important for the interference with antigen presentation, whereas SseF and SseG contributed to a lesser extent to this phenotype [41].
This paper is important for our presentation because it reflects the various ways the pharmaceutical industry can create a profitable market by pushing a system of asymmetrical information and incentives.
These exons determine the amino acid residues of the peptide binding groove that is important for antigen presentation.
This suggests that at least one of the deleted genes of chromosome 9 is important for correct presentation of PfEMP1 at the IE surface.
CD11b and CD11c are adhesion molecules that play a role in cell migration and phagocytosis, CD68 is involved in phagocytosis and MHCII is important for antigen presentation (Kettenmann et al., 2011).
Not every citrulline residue in a protein will provide a good epitope, however, because the amino acids flanking the citrulline residue are important for the presentation of the antigenic citrulline residue.
Macrophages and myeloid DCs are important for ongoing presentation of nucleosome-derived epitopes to autoreactive T cells in mice with established lupus [ 37, 38], and hyperactive APCs are a characteristic feature of lupus, playing a critical role in initiation and pathogenesis [ 39- 43].
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CEO of Professional Science Editing for Scientists @ prosciediting.com