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These findings suggest that dysregulation of ALDH2 activity through either genetic or environmental factors may be important for pathogenesis in PD patients from different ethnicities.
P. aeruginosa synthesizes and secretes at least two siderophores, pyoverdin and pyochelin, both of which have been shown to be important for pathogenesis of P. aeruginosa [1], [4].
This has been reported to be important for pathogenesis since deletion of methylcitrate synthase had a negative impact on pathogenicity [18], [50].
However, several of those genes encode potential transcription regulators, envelope proteins and secreted proteins (Table S1) and thus could be important for pathogenesis or adaptation to specific growth conditions.
Many of the virulence mechanisms used by bacterial pathogens to cause disease in mammalian hosts have also been shown to be important for pathogenesis in C. elegans and, similarly, important features of the host innate immunity have been evolutionarily conserved between C. elegans and mammals.
However, SAP may be important for pathogenesis at other sites or stages of infection.
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The C-terminal half of TDP-43 is important for pathogenesis.
Bacillus species respond to environmental pH in ways that are important for pathogenesis.
Some of these CDSs encode functions that are important for pathogenesis, such as the zinc metalloproteinase previously mentioned.
In order to determine whether HcDPPIVA is important for pathogenesis, we used a mouse model of histoplasmosis as previously described [17].
Being that poxvirus immune modulators are important for pathogenesis and viral interaction with the host cell environment, we used the poxvirus-human microarray to determine if, and when the putative MPXV interferon-modulating proteins were expressed during infection.
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