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This early peak disappears following cell proliferation indicating that while specific surface area may be important for initial cell adhesion, improved cell migration provided by scaffolds with pores above 300 μm overcomes this effect.
More importantly, rapidly acting post-translational feedbacks may frequently be important for initial signal processing and specificity [ 29, 35].
Along with the biochemical cues provided by RGDS and the MMP-2 degradable sequences, this property may be important for initial retention and survival of implanted CMs.
This result suggests that provider's endorsement may be important for initial patient engagement in the SMR, but subsequent use is more likely to be based on morbidity and other individual patient characteristics.
From analysis of molecular dynamics simulations, MM07 (cyclo[1 6]CRPRLCHKGPMPF) was expected to mimic the solution conformation of apelin-13 (NH2-QRPRLSHKGPMPF-COOH) and promote a β-turn conformation at the RPRL motif, suggested to be important for initial recognition and binding at the apelin receptor.
This finding contrasts previous belief that fibrous plant material degradation is linked specifically to hydrolysis of the main chains of cellulose and hemicellulose; rather, the wealth of enzymes that breakdown the side chains (galactans and arabinans 104) of these polymers appears to be important for initial colonization of fiber.
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For warfarin, genotying is important for initial dosing to avoid adverse events in initiation phase, but this does not supercede the need for therapeutic monitoring of anticoagulation.
Changes in cell stiffness are important for initial adhesive interactions during cell migration in vivo.
This is important for initial instrument design, such as format, content, understandability, terminology, and ease and speed of completion (Nunnally 1978).
Type IV pili (T4P) are important for initial adhesion and virulence [5].
In wing discs, data suggests that exocyst is important for initial delivery of DEcad to the plasma membrane [13].
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