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Residues in the ligand-binding domain known to be important for functionality of nuclear hormone receptors [ 24] are also conserved.
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Most proteins undergo some form of post-translational modification (PTM), which is important for functionality [39].
In biophysical and biochemical point of view, N-glycosylation sites and O-glycosylation sites are important for functionality of the protein.
The deduced amino acid sequence contains one putative N-glycosylation site, suggesting that glycosylation could be important for enzyme functionality.
Setting up new links and strengthening remaining ones in the lesioned neuronal populations might therefore be important for regaining functionality.
Myonuclear apoptosis is therefore a rare event also in old mouse muscle (0.8% of total myonuclei), which may nonetheless be important for the functionality of myofibres (Marzetti et al., 2010).
Cooperative binding of one or several distinct miRNAs to a single target gene has been shown to be important for the functionality of miRNA-mediated gene regulation [ 6, 7].
In addition, the presence and functionality of phase II enzymes involved in drug conjugation and of transporter proteins responsible for elimination and clearance of drug metabolites as well as for uptake of drugs will be important for the functionality of stem cell-derived hepatocyte-like cells in vitro.
This chapter describes the key characteristics and properties of scaffolds that are likely to be important for ensuring optimal functionality and consistency and identifies those features that should be considered in planning experimental test programmes.
The development of distinct self-assembling peptide systems with various functionalities will be important for tailoring and optimising biological performance, especially in relation to active scaffolds for tissue engineering and regenerative medicine.
This functionality appears to be important for the dissolution of the brush border after either prolonged fasting or increases in intracellular calcium [26].
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