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However, conformational variability is seen around Leu1706 which is a hot spot for cardiomyopathy mutations suggesting that this might be important for function.
While three-dimensional conformation may be important for function, it is not necessary for definition.
In mammalian systems, αPIX has been shown to be important for function of the immune system [79], but βPIX knockout has not been reported.
This conformational variability is likely to be important for function although there is no evidence that zinc is involved in vivo.
Finally, the conformational differences in the β4/β5 and β7/β8 loops of the two independent Spy0129 molecules point to a flexibility that may be important for function.
The additional stretches of residues, which lie in turns, flexible loops or the larger inserts, form secondary structural elements that were not modeled but may nevertheless be important for function.
Similar(48)
Protonation of a buried water cluster has been shown to be important for functions of bacteriorhodopsin as well (Garczarek et al., 2005).
One can expect that the longer exons are more likely to retain their functionality after shuffling so they are important for function and maintained in evolution.
An increasing number of enzyme systems show the presence of conserved protein motions that are important for function.
Full activity requires GTP hydrolysis, suggesting that a conformational change of the factor is important for function.
Pseudouridine has been identified in tRNAs, rRNAs, snRNAs and/or snoRNAs for which the stability of their tertiary structure is important for function [29], [33].
More suggestions(17)
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Justyna Jupowicz-Kozak
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