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Biochemical abnormalities usually present in rickets and osteomalacia are increased blood concentration of the enzyme alkaline phosphatase, believed to be important for bone formation or resorption, and decreased blood concentrations of calcium or phosphate or both; the calcium concentration may fall to levels so low that muscle and nerve function is impaired (tetany).
Previous studies have found that optimal vitamin D status may not only be important for bone health but also may protect people from some cancers and other chronic diseases.
Silicon may be important for bone and connective tissue health.
Growing evidence suggests that vitamin D may be important for bone health and other diseases, including those of the liver.
The RANKL complex, consisting of the membrane-bound RANK, its ligand RANKL, and the decoy receptor OPG, is thought to be important for bone metabolism.
The kidney is the major source of BMP-7 in the adult body, and BMP-7 appears to be important for bone homeostasis [ 43- 45].
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Since estrogen is important for bone health, it was long suspected that exemestane might be bad for bones.
Prof Matthew Wyon, head of dance science at the University of Wolverhampton, says: "Vitamin D is important for bone development and has a wide range of functions.
A functional immune system therefore is important for bone healing.
As precursors of bone-resorbing osteoclasts, monocytes are important for bone remodeling (Deng et al., 2011b; Zhou et al., 2015).
Monocytes may access bone resorption surfaces to differentiate into osteoclasts to resorb bone, which is important for bone remodeling and fracture repair (Deng et al., 2011a).
More suggestions(16)
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Justyna Jupowicz-Kozak
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