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The active ICAM-1 peptides have a common Pro-Arg-Gly sequence that may be important for binding to LFA-1.
The side chains of Asp133, Arg135, Val136, Leu139, and Tyr140 that were shown to be important for binding to a monoclonal antibody H8 mAb are surface exposed.
And from the E2 side, budding yeast Ubc9's N-terminal helix and β1β2-loop were also shown to be important for binding to Uba2 and formation of a Ubc9∼Sumo complex [37].
Proteases have been shown to be important for binding and entry in a wide variety of organisms and protease II is an S9A type protease, the type shown to be necessary for entry of Trypanosoma cruzi into host cells [36].
The residue at this location is conserved as either a tyrosine or phenylalanine among all APH(3'), APH 9), as well as APH(3″) enzymes, and shown to be important for binding and catalysis [20].
The intrinsic flexibility of the A scaffolding subunit [14] as well as the AC core dimer, which experiences profound conformational rearrangements after binding of the regulatory subunit [15], [16], has been proposed to be important for binding different regulatory subunits and for performing catalysis on a wide variety of substrates.
Similar(26)
A number of reports demonstrated that the UbA domains are important for binding of poly-Ub proteins whereas the UbL domain binds to proteasome [17].
In contrast, TCN did not bind, demonstrating that the phosphate group is important for binding.
Binding to STAT5b Trp641Ala was significantly reduced, suggesting that Trp641 is important for binding of the catechol bisphosphate core.
In S. cerevisiae it also contains three phosphorylation sites that are important for binding to the proteasome quality control factor, Ecm29 (Wani et al., 2016).
These results suggest that the characteristics of nanomaterials are important for binding with human blood proteins; this information may contribute to the development of safe and effective nanomaterials.
More suggestions(17)
be critical for binding
be important for determining
be important for restraining
be available for binding
be useful for binding
be valuable for binding
be necessary for binding
be optimal for binding
be ideal for binding
be beneficial for binding
be accessible for binding
be relevant for binding
be dispensable for binding
be responsible for binding
be sufficient for binding
be important for integrating
be important for interacting
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