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GBS pili have been shown to be important for adhesion of that pathogen to human BMEC, although in GBS adhesion required the presence of the ancillary subunit [28].
The ability of certain bacteria to manipulate the host's cytoskeleton in such a way is known to be important for adhesion and invasion [37] [39], and further work is required to confirm this observation and elucidate the specific mechanisms involved in this interaction.
Some genes encoding adhesins of the P97 family are absent in M. flocculare and some contain sequence differences or lack of domains that are considered to be important for adhesion to host cells.
The most rapidly evolving genes in C. pecorum are the genes coding for the PMPs, a family of proteins that may be important for adhesion of Chlamydia to host cells [ 4, 34, 35].
The LFA-1→ICAM-1 isteraction is known to be important for adhesion of lymphocytes to vascular endothelium as a precursor to extravasation and penetration of the extra-vascular space (Springer, 1990).
The interaction between lymphocyte function associated antigen-1 (LFA-1) expressed by lymphocytes and intercellular adhesion molecule (ICAM-1) on antigen presenting cells is known to be important for adhesion (Takahashi et al, 1993).
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These gene clusters encode adhesive pili that are important for adhesion and invasion of the host cells [ 27– 29].
Glycan array and cell adhesion assays indicate that these newly identified glycan-bacteria interactions are important for adhesion and possibly colonisation of host tissues during both infection and commensal colonisation.
rOmpA encodes a surface-expressed protein of SFG-rickettsiae that is important for adhesion to host cells (10).
a as described in Reference 40 NRG857containsns genes that are important for adhesion and invasion of AIEC LF82, including nlp1, htrA, yfgL, and dsbA [ 46- 49].
Secretin-family receptors, some of which have hormone receptor, immunoglobulin, fibronectin, or EGF domains at their N-termini and are more similar to adhesion GPCRs [ 62], exhibit increased expression in the adult where they may be important for intercellular adhesion, environmental monitoring, or as components of the sponge immune response (p < 0.0005, Fisher's exact test; Figure 6A).
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