Sentence examples for be important for activity from inspiring English sources
A pattern with large positive weight is expected to be important for activity of a compound while a pattern with large negative weight should represent inactive or non relevant parts of a molecule.
Mn2+ was found to be important for activity in case of the MutL homologs from humans (PMS2), yeast (PMS1), Thermus thermophilus (TthL) and Aquifex aeolicus (AaeL).
SLiMs typically consist of a 3 to 10 amino acid stretch of the primary protein sequence, of which as few as two sites may be important for activity, making identification of novel SLiMs extremely difficult.
Consequently, some of our peptide analogues contained unusual amino acids and/or structural features not present in native griffithsin to impose secondary structural features, which we hypothesized might be important for activity and multimerization.
Furthermore, a comparison with α-dendrotoxin showed that both molecules share several amino acids found to be important for activity (Leu7 and Lys27 in EgKU-1 are equivalent to Leu9 and Lys29 in α-dendrotoxin); a residue comparable to the Lys5 is, though, absent from the parasite molecule.
This could be important for activity on viral DNA and on transcription bubbles in the context of somatic hypermutation.
This suggests that Ag+ can induce a local folding in the enzyme loop and this folding is important for activity.
The docking studies of these molecules revealed that hydrogen bond formation with Arg221 is important for activity.
For Cryptococcus, the naphth-1-ylmethyl substituent at the 5-position and smaller cyclopentylamide- or cyclohexylamide groups at the 2-position were important for activity.
Miltefosine and other alkylphospholipids that are active in mast cell degranulation assays contain a positively charged nitrogen and a phosphate group that are important for activity.
