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We therefore measured the levels of HER1, HER2 and HER3, which were phosphorylated at tyrosine sites described to be important for activation of the receptors [ 20], as well as the levels of the activated form of the downstream target kinases Erk and Akt.
Recently, dimerization was shown to be important for activation.
Both receptors contained several tyrosine phosphorylation sites, which might be important for activation and internalization.
In addition, the precise location of Smo on the primary cilium may be important for activation of the pathway.
Human CXCR1 but not hCXCR2 was found to be important for activation of ROS [ 24].
Moreover, ATP hydrolysis by the MCMs has been reported to be important for activation (and hence ssDNA formation).
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The C-terminal activating region 2 (CTAR2) of LMP1 is important for activation of the NF-κB signaling via the host cell proteins TRAF6 and TAK1 [34], [34].
The protein stability mediated by ubiquitin E3 ligases is important for activation of DREB2A (Qin et al. 2011).
This inhibition of Wnt6 canonical signaling by Sfrp2 was important for activation of the non-canonical Wnt/Planar Cell Polarity (PCP) pathway through JNK, which in turn induced expression of cardiac transcription factors and CPC differentiation.
It is suggested that this elevation of VGLUT2 contacts on GnRH neurons is important for activation of GnRH neurons on proestrus.
NFIX is important for activation of GFAP transcription in astrocytes [19] and provides resistance against TGFB-induced apoptosis in mink epithelial cells [20].
More suggestions(15)
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be necessary for activation
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be sufficient for activation
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