The high stiffness of the pedicle rod system was supposed to be implicated with the role in accelerating degenerative changes at the adjacent levels of the spinal column [ 4- 7].
The anticancer activity of a natural product and fractional extract was also assessed by the capability to downregulate the expressions of oncogenes or to upregulate the cancer-suppressing genes, which were implicated with the change in mRNA transcription levels.
If a functional module is implicated with a disease, changes to a member gene in this module may cause this disease [ 23, 24].
Set shifting has been implicated with the need to change tasks.
There are also changes in a potentially adverse direction, e.g. the yields of formaldehyde and benzene, which also have been implicated with smoking-related carcinogenicity.
Other sites under selection M6, I12, also appear adjacent to residues predicted to form the antigen binding groove and these may also be implicated in structural changes associated with the repertoire of peptides presented to T cells.
Mechanisms regulating transport remain only partly understood in any organism, but transcriptional, post-transcriptional and post-translational processes are all implicated, with changes in transcription [ 17], complex kinase integration [ 18], and formation of multiple protein-protein interactions [ 19, 20] contributing to control.
Also changes in water content may be implicated (see " Water content, volume changes and altered vasculature").
Metabolomic profiling has tremendous potential to provide critical information about "when" a system is perturbed, information about "which" specific molecular pathways might be implicated, and about "how" profiles change with disease.
Climate change has only recently begun to be implicated as a cause of rapid phenotypic change, but cases are now being documented with greater frequency [3], [15].
