However, IR-A shows considerably higher affinity for IGF-1 and particularly for IGF-2 than IR-B [16], and has been implicated together with the IGF1R in malignant transformation [17], [18].
BoNT/A targets and cleaves the synaptosomal-associated protein of molecular weight 25K (SNAP-25), a protein associated predominantly with the plasma membrane, and which is implicated, together with syntaxin and the vesicular protein VAMP/synaptobrevin, in the fusion machinery of catecholamine-containing large dense core granules [16], [17].
Barley NP1 has been reported to be localized to the cell wall of nucellar cell types [ 19], while rice REP-2 has been implicated, together with REP-1, in storage protein degradation [ 20].
Thus in Australia, weedy Hordeum species have been implicated together with volunteer wheat plants as off-season (over-summering) hosts for Puccinia striiformis allowing this pathogen, that has no protected spore stage, to survive for the several months between maturity of one year's wheat crop and emergence of the next (Wellings 2007).
Who will be implicated then?
"I wanted to be implicated in it.
(Googling indicates that Baskin Robbins may be implicated).
PCSK1 may be implicated in malignancy [40].
However, many genes that have been implicated function together in pathways and interact with one another [Asbell et al., 2005; Bao et al., 2012; Cho et al., 2007; Chong et al., 2009; Martinez and de Iongh, 2010].
Cocaine and opioids together were implicated in four of the seven deaths attributed to accidental drug overdose (see online supplementary table S1).
