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These observations are particularly interesting as both efaCBA and sodA have been shown to be implicated in virulence [38], [82].
This in turn can affect the virulence of the bacterium and efaCBA has indeed been shown to be implicated in virulence [54].
These experiments demonstrated that ef_3196/7 operon seems indeed to be implicated in virulence confirming that R-IVET is a valuable tool to identify new fitness/virulence factors in E. faecalis.
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Protease inhibitors have been implicated in virulence of the oomycete plant pathogen Phytophthora infestans.
PB1 gene encodes a polypeptide of almost 80 amino acids, with specific polymorphism and has been implicated in virulence of virus with specific polymorphism (Chen et al., 2001).
Influenza viruses have several proteins that are implicated in virulence: the surface proteins hemagglutinin (HA) and neuraminidase (NA), the polymerase complex (including the PB1, PB2 and PA proteins), and the non-structural proteins [2].
PPK has also been implicated in virulence and in-vivo growth in several bacteria.
It has been proposed that lipoproteins are implicated in virulence in E. faecalis [56].
The entire region is transcriptionally regulated by MglA, which is implicated in virulence [16].
Type IV pili genes are implicated in virulence in Francisella tularensis as well as other pathogenic bacteria [18].
In addition, ARs 11, 30 and 34, which encode the pilus, pneumococcal collagen-like protein (PclA) and PsrP, respectively, have been implicated in virulence [10], [16], [19], [69].
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