It has been reported previously that NETs are implicated in tissue damage during E. coli sepsis [22].
Hippo signaling serves to limit organ size and suppress malignancies, and has been implicated in tissue regeneration following injury.
Recently, accumulated evidences support that connective tissue growth factor (CTGF) is implicated in tissue repair of many tissues.
In this respect, complement proteins have been implicated in tissue and organ regeneration in both urodeles and mammals.
Tissue resident macrophages have been implicated in tissue injury and repair (Yamasaki et al., 2014; Zigmond et al., 2014; Stamatiades et al., 2016).
Multipotent mesenchymal stem cells (MSCs) are widespread in adult organisms and are implicated in tissue maintenance and repair, regulation of hematopoiesis, and immunologic responses.
Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating cell-matrix interactions, has been implicated in tissue repair and foreign body responses.
ILC3s have also been implicated in tissue repair following inflammation or damage in multiple tissues, including intestines, thymi, and lungs (Dudakov et al., 2012; Sawa et al., 2011; Taube et al., 2011).
Mmp8 (formerly known as Collagenase 2) is implicated in tissue remodeling under inflammatory conditions, and in wound healing [38], [39], [40].
Moreover, DNA methylation is implicated in tissue specific gene expression.
