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Noticeably, this oscillatory behavior also seems to be implicated in stem cell fate determination: cyclic hes1 expression in embryonic stem cells seems to contribute to the heterogeneous response of the cells and low or high hes1 levels are determinant to specify cells to either a neuronal or mesodermal fate, respectively [ 82].
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These small RNA have been implicated in stem cell pluripotency and differentiation.
Notch signaling has been implicated in stem cell self-renewal [ 25].
BMP-2 is implicated in stem cells differentiation into osteoprogenitor cells.
MAGEC2 belongs to a family of CT antigens which had been implicated in stem cell differentiation pathways.
PolycombGroup (PcG) proteins maintain gene repression through histone modifications and have been implicated in stem cell regulation and cancer.
The encoded protein binds small RNA and has been implicated in stem cell pluripotency, metabolism and tumorigenesis.
Interestingly, several members of the PcG family have been implicated in stem cell regulation and malignancy, including breast cancer [ 1].
LSD1 has previously been implicated in stem cell pluripotency (Adamo et al. 2011), both in embryonic stem cells and in cancer stem cells.
In addition, LIN28A has been implicated in stem cell pluripotency and metabolism, is expressed widely in early embryogenesis, and is downregulated upon differentiation [ 7, 15].
In this study, expression of miR-302c was stimulated to the greatest extent (approximately 1.8-fold), and this miRNA has been implicated in stem cell pluripotency [ 77].
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