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Other mutations can still be implicated in resistance however, as described in LNZ-resistant Enterococci, Staphylococci and S. pneumoniae [ 21, 22, 26, 29, 36].
Changes induced in goblet cell populations and mucin glycosylation could be implicated in resistance to infection.
Indeed, many genes showed overexpression in the new microenvironment and if some of them might be overexpressed in response to the signals like cell-to-cell or cell-to-extracellular matrix contact, others might be implicated in resistance to stress.
Thus, these three gyrB mutations may not be implicated in resistance.
Several molecular mechanisms that may be implicated in resistance to rapalog mTOR inhibitors have been documented in laboratory model systems.
Among the 21 GyrB substitutions described in the literature, only two have been demonstrated to be implicated in resistance to FQ (N538D and E540V) [ 17].
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Androgen receptor splice variant 7 (AR-V7) has been implicated in resistance to abiraterone and enzalutamide treatment in men with metastatic castration-resistant prostate cancer (mCRPC).
P-gps have also been implicated in resistance to multiple insecticides and acaricides50.
Activation of the HER3/PI3K/Akt pathway in breast tumors has often been implicated in resistance to HER2-targeted therapies.
Solute carrier family 11 alsoSlc11a1; also known as NRAMP1) has been implicated in resistance to tuberculosis in humans, and possibly cattle [27], [28], [29].
More recently, MET amplification and activation via HGF/SF has also been implicated in resistance to EGFR inhibition in lung cancer [31], [34].
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