Other tested proteins included AML2 (AT2G42890), which is involved in embryo development, CRL (AT5G51020), which is implicated in pattern of cell division and MPK11 (AT1G01560), which influences differentiation and plastid division.
Wnt genes are implicated in patterning of the vertebrate body axis, through both canonical and non-canonical pathways [ 31, 32], and are thought to be important effector genes from Cdx gene activity [ 23].
Gαi/o proteins also act downstream of Fzd1 in the Wnt/Ca2+ pathway, and are implicated in patterning of the zebrafish embryo, likely through a cell-non-autonomous mechanism (Slusarski et al., 1997).
Beyond the placenta as reported here, Shh/Gli2 signaling has also been implicated in patterning and development of other tissues such as mouse embryos, skeleton, spinal cord, and hair follicle.
It follows that most of the other 96 genes uncovered by using the above mentioned topological parameters might also be implicated in expression patterns with a phenotype associated with heart tissue.
In contrast, less variability (16.6%) was explained by modeling AGAs, suggesting that additional variables we did not test may be implicated in driving prevalence patterns.
This confirmed the presence of genes from the pathways of known pigments (i.e. ommochromes) and indicated the presence of previously unknown pathways in spiders that may be implicated in the color patterning and polymorphism exhibited by these species (i.e. pteridines).
With respect to expression and function, ParaHox genes have been proposed to be implicated in bilaterian antero-posterior patterning of the endoderm in a collinear fashion comparable to Hox genes in the ectoderm [16].
EphA4 has previously been suggested to be implicated in myelination based on the expression pattern observed in hippocampal neurons at the onset of myelination (Tremblay et al., 2009).
This could explain the clustering of some common diseases in families and actually the epigenetic pattern could be implicated in transmitting a "predisposition" over generations.
