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NF-кB is believed to be implicated in multiple signaling pathways in variable physiological and pathological settings [31], and numerous therapies targeting the NF-кB pathways has been developed to protect patients against migraine [7, 11].
Glutamate- and K+-mediated Ca2+ influx has been reported to cause oligodendrocyte death and myelin disruption, and may be implicated in multiple sclerosis and ischaemia.
miR-21, a putative oncogene, is most frequently overexpressed in a variety of malignancies, especially in breast cancer, and it has been shown to be implicated in multiple malignancy-related processes including cell proliferation, apoptosis, invasion, and metastasis [ 26- 28].
miR-494, a well-known miRNA, is most frequently upexpressed in several different types of human cancers; and it has been found to be implicated in multiple cell processes including cell proliferation, apoptosis, and invasion.
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That being said, both hAT elements in general and piggyBac2_ML in particular have been implicated in multiple horizontal transfers (Pace et al. 2008; Gilbert et al. 2010; Pagan et al. 2010).
Machar says his troops have stopped fighting, but rebel forces have been implicated in multiple ceasefire violations.
The BRCA1 protein has been implicated in multiple cellular functions.
Open image in new window Figure 1 Iron is implicated in multiple cancer types.
Nitric oxide (NO) has been implicated in multiple physiological and pathological immune processes.
Aberrant activation of this pathway has been implicated in multiple cancers.
Aberrant c-Met activation has been implicated in multiple tumor oncogenic processes and drug resistance.
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