Dobzhansky-Muller incompatibilities have been implicated in intrinsic post-zygotic barriers [ 8] and involved in mito-nuclear gene interactions in the fruit fly Drosophila [ 5], the parasitoid wasp Nasonia [ 12- 14], the Atlantic eel Anguilla [ 15, 16] and the marine copepod Trigriopus californicus [ 4, 17, 18].
However, some features of IgG and IgM BCRs have been revealed to be implicated in distinguishing intrinsic functions of these receptors.
In view of the fact that trehalose octasulfate prolonged APTT and PT (APTT more than PT), its probable mode of action may be linked to the common pathway and can also be implicated in the intrinsic pathway.
The tyrosine kinase, c-Abl, is a protein belonging to the Src family of non-receptor tyrosine kinases that has been implicated in the intrinsic apoptosis pathway, triggered in response to DNA damage (Yamaguchi et al, 2010).
To gain further insights into the mechanisms involved in carbohydrate surfactant-mediated apoptosis, we investigated the dissipation of mitochondrial membrane potential (ΔΨm), an early facet in apoptosis that has been implicated in initiating the intrinsic pathway [38].
The rate of metabolism and cumulative oxidative damage to DNA and proteins, as well as genomic instability and mutations to mitochondrial DNA, have all been implicated in determining the intrinsic rate of cell aging and ultimately, species' life-span (Cevenini et al, 2008; Vijg & Campisi, 2008).
Furthermore, cancer-associated fibroblasts and the FGF/FGFR signaling pathway have been implicated in the development of intrinsic and acquired resistance to EGFR TKIs in patients with NSCLC 29– 329
Triptolide has been implicated in activation of both intrinsic and extrinsic apoptotic pathways by inducing caspase-8, −9 and 3 as well as by inducing cleavage of PARP [ 24, 25].
