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Since commitment of stem cells to the neuronal lineage is associated with repression of FOXD3 expression [ 33], it is reasonable to assume that its hyper-expression could be implicated in inhibition of neuroprogenitor differentiation.
TNFα may be implicated in inhibition of 1-α hydroxylase, which in turn alters the metabolism of vitamin D. 20 Table 1 shows the main known effects of HIV on osteoblasts and osteoclasts.
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Stabilised β-catenin has previously been implicated in inhibition of APC function in neurite formation and growth [51].
Cdkis encoded at the INK4a locus are implicated in inhibition of cell cycle progression and control of cell survival [30] [32].
The expression of clusterin, also known as apolipoprotein J is known to be induced by processes such as oxidative stress, as well as apoptotic stimuli and this protein has also been implicated in inhibition of neuroblastoma cell invasion [31].
Flavanoids have been implicated in inhibition of polar auxin transport [ 50- 53].
Overexpression of CXCL10 has been implicated in inhibition of the proliferation process in a variety of cell types.
p70S6K/S6 signaling has been implicated in inhibition of autophagy, and inactivation of the mTOR signaling pathway is a prominent consequence of PTEN activation.
82 Thus estrogen-related receptor alpha has a pivotal role in determination of mesenchymal stem cell fate and is implicated in inhibition of mineralization by osteoblasts.
Second, the prefrontal cortex is implicated in inhibition and contextual analysis in resolving the uncertainty, while the striatum plays a role in the evaluation of prospective risky outcomes [ 22, 23].
It has been reported that UV has been implicated in inhibition of anti-tumor T-cell immune response through elevated interleukin 10 (IL-10) and other cytokines level [ 21].
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