Despite being implicated in important cellular activities, few tetraspanins have been studied in detail, probably due to the difficulties imposed by their functional redundancy and subtle functions [17], [20].
TA class proteins represent 2.02% of all coding open reading frames in the human genome [30] and have been implicated in important aspects of cell physiology ranging from control of mitochondrial function, apoptosis and intracellular vesicular trafficking.
Leaf size and shape are implicated in important aspects as thermoregulation [40], [41], efficiency of water use [23], [42], photosynthetic potential [43], branching and rooting strategies [44], among others.
Cyclooxygenases (COX-1 and COX-2) convert arachidonic acid to bioactive prostaglandins (PG) and tromboxanes (TX), which have been implicated in important physiological functions [1], [2], as well as in the pathophysiology of several neurological and neurodegenerative diseases, such as stroke, epilepsy, and Alzheimer's disease [3].
MoRFs are implicated in important processes including signaling and regulation.
Calpain activity is implicated in important cellular processes including cytoskeletal remodelling, apoptosis and survival.
In essence, all of the TFs identified here have previously been implicated in important immune related settings [ 19- 26].
CAF have recently been implicated in important aspects of epithelial solid tumor biology, such as progression, growth, angiogenesis and metastasis.
Vitamin D (vitD) is is critical for the regulation of calcium and phosphate homeostasis and is implicated in important biological processes [ 1].
