Indeed, total O-GlcNAc and protein O-GlcNAcylation are elevated in the diabetic heart [ 4, 39], but the functional implications of this finding are unclear as elevated cardiac O-GlcNAc is implicated in heart failure and cardiac dysfunction [ 39, 40], but also cardioprotection [ 41, 42].
Hand-holding was found to reduce levels of cortisol, high levels of which are implicated in heart disease and other chronic conditions.
If the annoyance, pain and performance impairment of day-to-day anxiety isn't enough to quit these bad habits, perhaps this is: According to Harvard Medical School, anxiety is implicated in heart disease, migraines, chronic respiratory disorders and gastrointestinal conditions.
Meanwhile, research has shown that when people with high LDL cholesterol (the "bad" kind) purge their diet of saturated fats, they lower one kind of LDL (the large, buoyant particles called "Type A" LDL), but not the small, dense particles ("Type B" LDL) that are linked to high carbohydrate intake and are implicated in heart disease.
Canonical pathways enriched within our genes of interest have previously been implicated in heart development and some of the pathways appear to be interconnected.
Other significant pathways that have previously been implicated in heart development include ribosomal proteins [55], the actin cytoskeleton [52], Wnt signaling [56], and cytokine-cytokine receptor interaction [57].
SNP substitution E502K is implicated in heart disease [ 27].
