Three catalogs of human gene annotation were used to analyze EIAV integration site distributions, since LEDGF/p75 had previously been implicated in directing HIV integration to transcription units.
The superior parietal lobe has been implicated in directing visual attention to locations [33], and activation in this region often co-occurs with activation in the dorsolateral frontal regions (i.e., FEF) [34].
As such, TRAF6 has been implicated in directing the signals from representative members of a diverse array of receptor families, including the TNF receptor superfamily (TNFRSF), IL-1R/Toll-like receptor superfamily (IL-1R/TLRSF), TGFβR, IL-17R and IL-25R, and the NOD-like pattern recognition receptors [7], [8], [9], [10], [11], [12], [13].
To date, several intermediary 'nutrient sensing' molecules, such as those characterised in Saccharomyces cerevisiae and bacteria, have been implicated in directing amino acid signalling to mTOR [ 23, 24].
Recently, localized plumes of Ca2+ have been implicated in directing the highly localized deposition of individual papillae wall ingrowths in epidermal TCs of V. faba cotyledons [ 32].
The Snrpn cluster produces a poorly understood set of ncRNA transcript variants that are implicated in directing the imprinted expression of other genes within the cluster.
Similar to the Hedgehog pathway, the Wnt pathway is implicated in directing embryonic growth, and governing processes such as cell fate specificity, proliferation, polarity, and migration.
In addition to its Myb domain, TRF2 possesses an N-terminal domain rich in basic residues that has been implicated in directing the binding of TRF2 to ss dsDNA junctions and unusual DNA structures.
NuRD-mediated deacetylation can direct the activity of the polycomb repressive complex 2 (PRC2) to silence gene expression (Reynolds et al., 2011), and NuRD has also been implicated in directing DNA methylation to a target gene in leukaemia cells (Morey et al., 2008).
Despite the known function of the core planar polarity pathway in promoting cell intercalation, so far there is little evidence that it might play this role during tubulogenesis, although it is implicated in directing oriented cell divisions in kidney tubules (Saburi et al., 2008).
