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In several types of tumors, including neuroblastoma, the shortest regions of overlap for 1p deletions partly coincide, indicating that the same TSGs may be implicated in different types of tumors [12].
Each protein may be implicated in different functions i.e. a protein may belong to different groups.
It has been hypothesized that CYP2D6 phenotypes may be implicated in different adverse events associated with gefitinib and erlotinib therapies.
Briefly, methylation of DNA in gene bodies is considered as the ancestral pattern in animal genomes and may be implicated in different functions than promoter methylation (26– 26).
These two LMW-PTP isoenzymes have different molecular and catalytic properties, suggesting that they may be implicated in different biological functions in the cell [ 5, 7].
As is the case with the PFC [13], different striatal sub-regions may be implicated in different forms of flexible behaviour.
Similar(52)
Numerous cues have been implicated in different instances.
It has been shown that SOX2, MYC and OLIG2 are required to maintain proliferation in progenitor cells and they have been implicated in different types of cancer28,51,52,53,60.
It is a novel member of the BCL2 gene family, members of which are implicated in different hematological malignancies.
Wnt signalling pathway has been implicated in different stages of mammary gland development as well as mammary oncogenesis [29,30,31], and it controls the expansion of the MaSC/early progenitor pool.
miR-21, a mature miRNA, has been implicated in different cell processes such as cell proliferation, mitochondrial damage, cell growth, chemosensitivity, cell cycle, genome instability, response to stress, mRNA cleavage, cell invasion and translation.
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