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Exact(2)
The conserved 5′ region encodes the highly conserved Pbx-interacting Meis (hth) domain and DNA-binding homeobox (Berthelsen et al. 1998; Mukherjee and Bürglin 2007), and the intervening introns may be implicated in developmental transcriptional regulation.
In regards to the GC-poor localization of the genes that are not expressed in any of the three adult mouse tissues considered here, the notion that they may be implicated in developmental processes is supported by several studies.
Similar(58)
The three highly homologous human RUNX TFs (RUNX1, 2, and 3) have been implicated in developmental processes and, notably, in cancer.
PBDEs/OH-PBDEs have been implicated in developmental neurotoxicity.
Differential DNA methylation has been implicated in developmental outcomes of early-life nutrient restriction [ 34].
KLFs are implicated in developmental as well as pathologic vascular processes.
PCBs are neurotoxic and have been implicated in developmental problems, so detection of PCBs in children is of particular concern.
Among 31 TFs that had significant 8-mer matches, 28 were implicated in developmental processes and many were homeobox TFs.
Members of the CCN family have been implicated in developmental processes such as chondrogenesis, osteogenesis, and angiogenesis.
Three converging lines of evidence have suggested that cerebellar abnormality is implicated in developmental language and literacy problems.
In Arabidopsis, LUG and TOPLESS (TPL) are the most studied Gro/Tup1 co-repressors that are implicated in developmental processes and hormone signaling [ 9, 12, 13].
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