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The BDNF Val66Met polymorphism may be implicated in depression and is also hypothesized to influence pain mechanisms [16], [17].
Some clinical evidence has supported the hypothesis that low levels of ω-3 FAs may be implicated in depression.
Since intracerebroventricular injection of CRH induces symptoms of depression in rodent [ 87], centrally released CRH may be implicated in depression etiology.
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Adult neurogenesis is implicated in depression and Alzheimer's disease, both of which involve hippocampal shrinkage.
Located toward the front of the brain, the structure has been implicated in depression and, intriguingly, altruistic behavior, and is thought to help negotiate between emotion and cognition, impulse and calculation.
In addition, TNF has been implicated in depression and irritable bowel disease [18, 19], recognized as migraine comorbidities [20, 21].
And their brains showed signs of their emotional pain, with heightened activity in the parahippocampus and other emotion-related areas that have been implicated in depression.
Although serotonin has been implicated in depression, obsessive-compulsive behaviors, eating disorders, and aggressiveness, the brain chemical dopamine--which is part of the brain's reward system--has gotten almost all of the attention in addiction studies, White says.
Low BDNF has also been implicated in depression as well as impaired cognitive functions such as learning and memory.
The subgenual MPFC, in particular, has been implicated in depression [59] [60].
Similarly, the prefrontal cortex has been implicated in depression and in bipolar disorder, but alterations in complex I were either sporadic or absent.
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