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They have been shown to be implicated in cholesterol turnover, inflammation and in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis.
Oxysterols have been shown to be implicated in cholesterol turnover, inflammation and in neurodegenerative diseases such as Alzheimer's disease (AD) [3], [4] and multiple sclerosis (MS) [5], [6].
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Moreover, plasmalogens have been implicated in cholesterol transport.
Both CETP and LIPC have previously been implicated in cholesterol homeostasis in other genome-wide association studies [4], [9], [10], [12], [16].
Calmin has not previously been implicated in cholesterol or lipoprotein metabolism nor has CLMN variation been associated with any metabolic traits.
LAMP-2 has been implicated in cholesterol transport from the lysosome [ 18, 24].
The SORL1 protein belongs to a super family of low-density lipoprotein receptors that bind apolipoprotein E and have been implicated in cholesterol metabolism [ 42].
Among these, isopentenyl-diphosphate delta-isomerase 1 (idi1), lanosterol 14-alpha demethylase (cyp51a1), farnesyl pyrophosphate synthase (fdps), c-4 methylsterol oxidase (sc4mol) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hmgcr) genes [ 44- 49] are known to be implicated in the cholesterol metabolic pathway.
Indeed, miR-34a has been shown to be implicated in the dysregulation of cholesterol metabolism by targeting the hepatic NAD-dependent deacetylase Sirtuin 1 (SIRT1), which is critically involved in the modulation of liver cell apoptosis, metabolic disease, and cancer [ 52, 53].
Defects in brain cholesterol metabolism has been shown to be implicated in neurodegenerative diseases, such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and some cognitive deficits typical of the old age.
"I wanted to be implicated in it.
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