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Many of the detected genes have been reported to be implicated in carcinogenesis and some modules are involved in known pathways.
Furthermore, this expression pattern suggests that ERH might be implicated in carcinogenesis and tumour-progression and this should be further investigated in appropriately designed functional studies.
Polymorphisms in the NER pathway may be implicated in carcinogenesis due to their potential to alter the DNA repair capacity of the host [ 10].
DNA hypermethylation of the cell cycle control gene RB (retinoblastoma) was one of the first epigenetic lesions to be implicated in carcinogenesis.
Individuals with ESRD commonly receive erythropoietin for treatment of anemia, which might be implicated in carcinogenesis and could potentially explain some of the observed excess cancer risk among individuals with ESRD [ 24].
In such an instance, BK virus may be implicated in carcinogenesis, although the antibody titers at the time of this study have returned to the range of normal individuals.
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EBV has been implicated in carcinogenesis since the discovery of its implication in Burkitt's lymphoma in sub-Saharan Africa in the 1960s [ 9].
The acyl-CoA synthetase 4 (ACSL4) has been implicated in carcinogenesis and neuronal development.
Chronic inflammation has been implicated in carcinogenesis, with increasing evidence of its role in lung cancer.
Individual components of the innate and adaptive immune response have also been implicated in carcinogenesis.
The HBV regulatory protein X (HBx), which is degenerate in avian HBVs, has been implicated in carcinogenesis.
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