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Overexpression of HDAC1, a member of Class I histone deacetylase is reported to be implicated in breast cancer.
Many genes of the BCL2 family were found to be implicated in breast carcinogenesis and to serve as possible prognostic markers.
The estimation of statistical significance revealed a significant overlap between the two studies (One-tailed Chi-square test p-value = 1.17×10−2), providing further evidence that many of the significant genes that are common to both studies may be implicated in breast cancer metastasis – as they were detected by independent groups, using slightly different experimental approaches.
Transforming growth factor-beta (TGF β 1 is thought to be implicated in breast cancer progression.
If TCR is responsible, DNA damage by bulky adducts may be implicated in breast cancer pathogenesis.
A number of miRNAs have been found to be implicated in breast cancer [ 4].
Similar(38)
Heat shock protein 90 (Hsp90) overexpression has been implicated in breast carcinogenesis, with putative prognostic and therapeutic implications.
Protein kinase C (PKC), a family of serine-threonine kinases, has been implicated in breast cancer progression (Urtreger et al., 2012).
Furthermore, estrogen stem cell cross talk has been implicated in breast cancer progression and results in increased tumor cell proliferation, angiogenesis and invasion.
The ribosomal protein p70S6K has been implicated in breast cancer cell response to post-surgical inflammation, supporting the hypothesis that it may be crucial also for breast cancer recurrence.
This will include molecular and cellular alterations that are known to contribute to breast cancer in humans, as well as pathways and processes that have been implicated in breast cancer on the basis of animal models.
More suggestions(16)
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