Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states.
The PI3K/AKT signaling pathway has also been implicated in altering breast cancer response to multiple therapies [1], [10], [11], [14].
More recently, Myc deregulation has been implicated in altering cellular metabolism, particularly by inducing both the Warburg effect and a reliance on exogenous glutamine [18], [25], [49].
In light of the current data set, we propose that a non-canonical mechanism (perhaps associated with metabolic dysfunction) is implicated in altering the calcium regulation in LCR myocytes thus giving rise to the contractile dysfunction observed in these hearts.
The electrostatic properties of helix macrodipoles have previously been implicated in altering the reactivity (significantly reducing the pKa) of cysteine residues positioned at the N-termini of α-helices [30].
Whereas the low levels of hypophosphorylated RB1 reported for other Lmna/LMNA deficient cells have been implicated in altering the G1/S transition, our findings with LmnaDhe/+ fibroblasts suggest that the influence of RB1 extends to mitosis as well [11], [19], [26], [28], [39] [42].
As chemo- and radiotherapy have previously been implicated in altering methylation patterns, no subjects who had received either type of treatment were included in the study.
128 Finally, increases in this essential bacterial micronutrient have been implicated in altering reef community structure and function in extremely oligotrophic environments, such as isolated coral atolls.
