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Klotho is a single-pass transmembrane protein, which appears to be implicated in aging.
Obviously, the 37 biomarkers measured here represent a tiny fraction of the molecules and systems likely to be implicated in aging (Medvedev, 1990; Kirkwood, 2011).
18 Therefore, overexpression of Wnt proteins may be one of the pathogenic factors to be implicated in aging, and klotho is a secreted Wnt antagonist.
Oxidative stress may be implicated in aging, carcinogenesis, and other degenerative diseases, and the analysis of urinary excretion of 8-OHdG is a useful approach to assess individual cancer risk due to oxidative stress (Kasai 1997).
Klotho is a single-pass transmembrane protein with a long extracellular domain and a short cytoplasmic tail, which appears to be implicated in aging, and regulates both the mineral transport and signaling mediated by fibroblast growth factor 23 (FGF23) [ 1, 2].
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In addition, they have been implicated in aging and neurodegeneration, including AD28,29,30,31.
The mitochondria have also been implicated in aging and the development of diseases such as cancer.
Oxidative damage and mitochondrial dysfunction are implicated in aging and age-related neurodegenerative diseases, including Huntington's disease (HD).
Reduced telomere length, or its accelerated attrition, has been implicated in aging, mortality, and several human diseases, including respiratory diseases.
Telomere uncapping has been implicated in aging and cancer, yet the precise mechanism of uncapping and its relationship to cell cycle remain to be defined.
Furthermore, mitochondria and their metabolism have been implicated in aging and several human diseases, including inherited mitochondrial disorders, cardiac dysfunction, heart failure, neurodegenerative diseases, diabetes, and cancer.
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