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Interestingly, we have determined that the up-regulation of VEGF relied on HIF-1α/GPER signaling also in HL-1 cardiomyocytes exposed to hypoxia, suggesting that this transduction mechanism may be implicated in additional pathophysiological conditions, such as the hypoxic myocardium.
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eEF1A1 has been implicated in additional non-canonical functions (reviewed in [8]), including actin-binding and bundling [9], apoptosis [10], nuclear transport [11], proteasomal-mediated degradation of damaged proteins [12], heat shock [13] and transformation [14].
Mast cells are also well-known for their role in allergic response and, more recently, have been implicated in additional innate and adaptive immune responses.
However, side effects of these drugs are implicated in additional bone marrow pathologies (Baillou et al. 2003; Hernandez-Vallejo et al. 2013).
The preening-mediated infection mechanism could be implicated in AIV dispersal in nature, but additional work is required to determine how this mechanism could affect the long-distance movements and long-term infectivity of AIVs.
Nevertheless, the observed inhibition of Satb1 expression in these experiments was only partial, suggesting that additional mechanisms may be implicated in the induction of this gene.
"I wanted to be implicated in it.
PCSK1 may be implicated in malignancy [40].
Apart from RTS-associated tumors, loss-of-function in p300/CBP has been implicated in several additional cancers with somatic mutations in p300 or CBP.
For example, in a review of egg-associated S. enterica serotype Enteritidis outbreaks (35 ), eggs were implicated as simple food vehicles in 20% of the outbreaks, but complex foods containing eggs were implicated in an additional 57% of the outbreaks.
VIM and CDH4 were implicated in invasive cancer (Additional file 8: Table S4B).
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