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It incorporates their ease-of-use, while providing advanced analytic methods that can be implemented in packages such as Stata, R and SAS by a statistical programmer.
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This meta-analysis strategy is implemented in software packages such as rareMETAL [ 62] and skatMeta [ 63] (see also [ 64]).
The SFDR procedure can be implemented in the software package R using the function p.adjust.
All the methods can be implemented in R package PKgraph (http://cran.r-project.org/web/packages/PKgraph) [ 14].
Our approach can be implemented in standard statistical packages.
Many of these algorithms have been implemented in various packages including the Vienna RNA package [ 48] and the RNAstructure Web servers [ 49].
The simplest is POA (Partial-Order Alignment); a similar but more generalized method is implemented in the packages SAM (Sequence Alignment and Modeling System).
All these methods were implemented in R packages written by Wang [ 10] and Lian [ 11].
The algorithms and methods described in this paper have been implemented in Matlab packages, which are attached as Additional files.
These methods have been implemented in many packages including UNAFold [ 13], Mfold [ 14], Vienna RNA Package [ 15], RNAstructure [ 16].
Several variants of these procedures are implemented in standard software packages used to analyze epidemiological data.
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