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Often, baseline characteristics of patients may be imbalanced between groups, and adjustments are needed to account for this.
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HCV viral load was imbalanced between groups at screening (log10 transformed mean: 5.9 for the EVR+Reduced group versus 5.6 for the TAC Control group) which was maintained at month 12 (6.6 and 6.1, respectively).
These models will be presented without adjustment, and a second set of analyses will be conducted with adjustment for any variables found to be imbalanced between the groups (if necessary).
However, when the data were adjusted for baseline clinical factors associated with relapse rate that were imbalanced between treatment groups, the ARR in the placebo group increased to lead to a statistically significant advantage for laquinimod over placebo [ 159].
In the multivariate linear model which is based on data from study 1, the interaction between SVC and AN may also be mediated by those other covariates which are imbalanced between the groups with and without AN grade 4.
Measures of ADL impairment are important in observational studies as ADL may be a strong predictor of outcomes such as mortality [ 7- 11] and long-term care (LTC) placement [ 12- 15] and may act as a confounder if ADL impairment is imbalanced between comparison groups [ 16].
This analysis will be adjusted for any baseline patient characteristics that are imbalanced between the two groups.
Age (dichotomized at e.g. 50 years), was imbalanced between the exposure groups: of those exposed 75% were of old age, whereas 25% of those unexposed were of old age.
Several factors were imbalanced between the three age groups.
Analysis will be 'intention to treat' and where appropriate regression analysis will be adjusted for baseline outcome measure and any baseline variables that are imbalanced between the two study groups.
Prior to propensity score matching, the observed covariates were imbalanced between the treated and control groups, particularly rupture of membranes at presentation and antenatal care provider type.
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