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Maximizing throughput means that a maximum number of particles should be imaged within a given time frame, so that a prespecified precision is attained.
It allows labelling of numerous molecular tracers that can be imaged within a few hours (typically <3 h) after injection.
C. intestinalis is ideal for imaging and, unlike its larger chordate cousins, large portions of the animal can be imaged within a single field of view.
With the development of molecularly targeted therapies and drug combinations requiring evaluation of different schedules, the number of animals to be imaged within a PET experiment has increased.
The number of animals that require to be imaged within a single small-animal PET (SA-PET) experiment is driven by the number of groups planned for the experiment, including controls and treatment arms.
High-speed image acquisition at 125,000 A-scans/s, compared to previously reported 25,000 A-scans/s [ 12], allows a dramatic decrease of motion artifacts and increases the field of view that can be imaged within a few seconds in a single volume acquisition.
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Compared with 99mTc-MDP, F-NaF has several advantages including rapid bone uptake and blood clearance, it can be imaged within an hour of i.v. administration, and it has an excellent signal-to-noise ratio [ 7, 8].
In SEFC, a transverse spectrally encoded line is imaged within a vessel, recording a reflectance image of the cells flowing across it (Fig. 1(a) ).
In cryo-EM, where filaments are imaged within an ice film of finite thickness, such tilt cannot be ignored, particularly as one becomes more sensitive to it the higher the resolution.
When evaluating a configuration where multiple animals are to be imaged within the FOV of a PET scanner, the physics issues mentioned above could be addressed with the NEMA NU 4 image-quality phantom (Fig. 1).
Point visiting was used to allow multiple positions to be imaged within the same time-course.
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