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We demonstrate that NHEJ repair "fingerprints" can be identified using our assay, which are dependent on the status of key DSB repair proteins.
Studies that evaluated whether type 1 diabetic patients overreport or underreport dietary intake associated with their weight status could not be identified using our search strategies.
First, it is possible that some sequences belonging to the Firmicutes or Bacteroidetes phyla may not be identified using our method since the sensitivity of our DNA barcode is less than 100%.
Since the direct gene target (the transcriptional repressor in the example above) of the microRNA should already be identified using our method, such an analysis would extend the regulation network beyond first order interactions.
Hence, 1D C HSQC-TOCSY traces from 2D C H HSQC-TOCSY spectra cannot always be identified using our previous C-TOCCATA database with optimal accuracy, which explains the need to include C traces in the H(C -TOCCATA database.
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To our best knowledge, this is the first report that more than 40 variants of lipopeptides from one strain of Bacillus were identified using our potent purification and identification methods.
We describe herein the affinity optimization of an initial hit to give 2- 2-chlorobenzylamino -1- cyclohexylmethyl -1H-benzo[d]imidazole-5-carboxamide (1), which was identified using our proprietary Automated Ligand Identification System (ALIS).1 The X-ray co-crystal structure of 1 was solved and revealed several key interactions and opportunities for further optimization in the ATP site of AccC.
Haplotype tagging SNPs were identified using our previously published approach [4].
Of the common melanosomal proteins 79 out of 100 were identified using our method.
A structural and functional relationship between the bacterial T3SS and eukaryotic apoptosis was identified using our FAST-NMR ligand affinity screen in combination with a bioinformatic analysis based on our CPASS program.
Seventeen studies investigating Southeast Asian populations were identified using our search criteria (Table 1).
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