In invertebrates, similar currents have also been identified to modulate various CPG network models [11], [22], [37].
In a meta-analysis of 42 studies NAT2 has been identified to modulate susceptibility to colorectal cancer [ 19, 20].
In addition, novel targets such as ALDH1A1 and EMP3 were identified to modulate the toxicity of saturated FFA.
prior-knowledge was obtained using Pathway Studio 8. 543 gene-to-TF relations were extracted where a DETF was identified to modulate the expression of a potentially regulating TF.
Some other residues (L556A/L558A and M560/L561) (32), including Pro582 (33), were identified to modulate the transactivation but not stability of HIF in hypoxia in other experimental conditions.
Several molecules have been identified to modulate GH signaling, including suppressors of cytokine signaling (SOCS), cytokine-inducible SH-2 containing (CIS) protein, and peroxisome proliferator-activated receptor gamma (PPAR γ), which directly inhibit phosphorylation or transcriptional activity of JAK and STAT.
Some factors have been identified to modulate metabolic processes in the diseased pulmonary vasculature, but the entire complement of regulators remains undefined.
Although 16 of 276 conducted tests reached nominal P < 0.05 (Table S8), no associations remained significant after multiple testing correction and none of the involved CpG sites were identified to be modulated by meQTLs.
53 compounds were initially identified to modulate the activity of ALDH2 by a high-throughput esterase screen from a library of 63,000 compounds.
The tumor suppressor protein p53 was recently identified to modulate miRNA processing through association with p68 and Drosha, similar to the Smads.
